In ePO 4.x, test the connection by navigating to Menu, Configuration, Server Settings and click Email Server. Enter the email address and click Test to send test email. When this issue occurs, an error similar to the following is logged in orion.log:
"email was unsuccessful due to an unknown error. the message could not be sent because of an unexpected error"
"No mail recipients com.mcafee.orion.response.command.SendEmailCommand.invoke"
NOTE: The option for sending test email is not available in ePO 5.x.